I rarely (read: never) want to tweet when I right click to bring up a context menu. Actually, most of the time, I'm just looking for "Inspect Element" in Chrome. I was happily surprised to find I could remove the option entirely:
- Open System Preferences
- Choose "Keyboard"
- Choose the "Keyboard Shortcuts" tab
- Find "Services" in the menu
- Untick "Tweet" (I also found a few others to untick)